Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment

(2017) Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment. Iranian Journal of Pharmaceutical Research. pp. 1223-1229. ISSN 1735-0328

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Abstract

Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin, in which loss of adhesion between keratinocytes is caused by autoantibodies. It has been hypothesized that cytokines play an essential role in the pathogenesis of PV. This study aimed to investigate the other immunopathological aspects of PV by determining the serum levels of cytokines in PV patients to find another treatment strategy except corticosteroid therapy. Twenty-three patients with PV and a control group consisting of 24 healthy subjects were studied. Interleukin (IL)-2, IL-4, IL-6, IL10, IL-12, IL-17 and interferon-gamma (IFN-gamma) were measured in the sera of patients by the enzyme-linked immunosorbent assay (ELISA) method. The serum levels of IL-2, IL-4, IL-17 and IFN-gamma in most patients and controls were undetectable. The serum concentrations of IL-10 in the patients and controls were undetectable, nevertheless, the mean serum levels of this cytokine was 64.375 pg/mL in four patients. The mean serum levels of pro-inflammatory cytokine IL-6 increased significantly in the patients, compared to the controls (169.50 vs. 75.62 pg/mL) (P < 0.05). The same was observed for another pro-inflammatory cytokine, IL-12 (135.33 vs. 86.28 pg/mL) (P < 0.05). Based on the results of this study it can be concluded that the Type 2 T helper cytokine (IL-6) and macrophage-derived cytokine (IL-12) have essential roles in PV pathophysiology. In addition, the potential clinical application of Th1/Th2 type cytokine-based therapy in PV should be considered in next studies.

Item Type: Article
Keywords: pemphigus vulgaris th1 cytokines th2 cytokines interleukin interferon t-cells th1 therapy differentiation pathogenesis subsets serum il-6
Divisions: Cardiovascular Research Institute > Applied Physiology Research Center
Faculty of Medicine > Department of Basic Science > Immunology Department
Faculty of Medicine > Departments of Clinical Sciences > Department of Skin
Faculty of Pharmacy and Pharmaceutical Sciences > Student Research Committee
Skin Diseases and Leishmaniasis Research Center
Page Range: pp. 1223-1229
Journal or Publication Title: Iranian Journal of Pharmaceutical Research
Journal Index: ISI
Volume: 16
Number: 3
ISSN: 1735-0328
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/484

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