(2017) Cognitive enhancing of pineapple extract and juice in scopolamine-induced amnesia in mice. Research in Pharmaceutical Sciences. pp. 257-264. ISSN 1735-5362
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Abstract
The objective of the present study was to evaluate the cognitive enhancing of pineapple juice and ethanolic extract in scopolamine-induced cognitive deficit mice. The ethanolic extract of pineapple (Ananas comosus (L.) Merr.) was prepared by maceration method and its juice was obtained by a homogenizer. Object recognition task was used to evaluate the mice memory. Exploration time in the first and second trial was recorded. The differences in exploration time between a familiar and a novel object in the second trial were taken as a memory index. Animals were randomly assigned into 15 groups of 6 each including: control group (normal saline + vehicle), positive control group (scopolamine + rivastigmine), seven experimental groups (received scopolamine alone or scopolamine + ethanolic extract of pineapple in different doses), six other experimental groups were treated by ethanolic extract or juice of pineapple in different doses. Scopolamine (100 mL, 1 mg/kg, i.p.) and pineapple juice or extract (50, 75 and 100 mg/kg, i.p.) were administered 40 and 30 min before starting the second trial in the experimental groups. Object discrimination was impaired after scopolamine administration. Results showed that juice and ethanolic extract of pineapple significantly restored object recognition ability in mice treated with scopolamine. These finding suggested that pineapple had a protective role against scopolamine-induced amnesia, indicating its ability in management of cognitive disorders.
Item Type: | Article |
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Keywords: | alzheimer's disease amnesia object recognition task pineapple scopolamine alzheimers-disease cholinergic hypothesis inhibitory-activities huperzine-b in-vitro acetylcholinesterase donepezil bromelain memory inflammation |
Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > گروه شیمی دارویی Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacotherapy Faculty of Pharmacy and Pharmaceutical Sciences > Department of Toxicology and Pharmacology |
Page Range: | pp. 257-264 |
Journal or Publication Title: | Research in Pharmaceutical Sciences |
Journal Index: | ISI |
Volume: | 12 |
Number: | 3 |
Identification Number: | https://doi.org/10.4103/1735-5362.207198 |
ISSN: | 1735-5362 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.mui.ac.ir/id/eprint/516 |
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