Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study

Abstract

Purpose: Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, external ocular inflammatory disorder that mainly affects patients in their first or second decade. This study was designed to compare tacrolimus and interferon alpha-2b (IFN alpha-2b) eye drops in the treatment of VKC. Methods: In this randomized, double-masked clinical trial, 40 consecutive patients with VKC were sent to a referral eye hospital in a tropical region southeast of Iran. Patients were randomly assigned to receive either 0.005 tacrolimus or IFN alpha-2b (1,000,000 units/ cc). Chi-square and t tests were used for comparison of outcomes between both groups. Results: Mean +/- SD age was 11.1 +/- 5.2 years. Thirty-one patients (77.5) were male. The mean duration of disease was 3.4 +/- 2.9 years. In this study, the signs and symptoms were significantly reduced in patients after treatment in both groups (P = 0.0001). In the tacrolimus group, all patients responded to treatment whereas only one subject in the IFN group failed to respond (P = 0.99). Side effects in both groups were mild and tolerable. Conclusions: This study indicated that both 0.005 tacrolimus and IFN alpha-2b are effective and appear to be safe in treatment of recalcitrant VKC.