(2017) The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by gamma-Irradiation in Mice Blood Lymphocytes. Dose-Response. ISSN 1559-3258
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Abstract
In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) against gamma-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body gamma-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated. The results of the alkaline comet assay showed that RSV significantly inhibited radiation-induced DNA damage. We observed that RSV protects blood lymphocyte against radiation-induced damage in mice.
| Item Type: | Article |
|---|---|
| Keywords: | resveratrol radiation comet assay lymphocyte radioprotective induced DNA-damage peripheral-blood individual cells comet assay in-vitro radiation antioxidant phytoalexins radiotherapy apoptosis |
| Divisions: | Faculty of Medicine > Department of Basic Science > Department of Medical Physics |
| Journal or Publication Title: | Dose-Response |
| Journal Index: | ISI |
| Volume: | 15 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.1177/1559325817705699 |
| ISSN: | 1559-3258 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mui.ac.ir/id/eprint/543 |
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