(2015) Serum inflammatory markers in obese mice: Effect of ghrelin. Advanced biomedical research. p. 145. ISSN 2277-9175 (Print) 2277-9175 (Linking)
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Abstract
BACKGROUND: Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice. MATERIALS AND METHODS: Ghrelin (100 mg/kg/day, twice daily) was administered interaperitoneally to control and diet-induced obese mice. After 10 days, blood samples were taken. RESULTS: Results showed that administration of ghrelin did not change serum hsCRP level; however, it reduced serum IL-6 concentration in obese mice (P < 0.05). CONCLUSION: It seems that the exact role and mechanism of ghrelin in prevention or treatment of atherosclerosis needs more studies.
| Item Type: | Article |
|---|---|
| Keywords: | C-reactive protein ghrelin inflammation interleukin-6 obesity |
| Page Range: | p. 145 |
| Journal or Publication Title: | Advanced biomedical research |
| Journal Index: | Pubmed |
| Volume: | 4 |
| Identification Number: | https://doi.org/10.4103/2277-9175.161556 |
| ISSN: | 2277-9175 (Print) 2277-9175 (Linking) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mui.ac.ir/id/eprint/5596 |
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