Effect of a trial pharmaceutical solution on reversing sensations after using lidocain: An animal study

Abstract

INTRODUCTION: Local anesthesia has a paramount role in any branches of medical sciences specially dentistry. Soft tissue irritations and lips biting are adverse side-effects in some cases. This study tried out to represent a new pharmaceutical solution in returning sensations faster. MATERIALS AND METHODS: Five New Zealand laboratory rabbits were anesthetized with 1 cc Ketamine and Xilosine intramuscularly in thigh site. Electrodes were attached to the palms and wrists. Then, 0.2 cc lidocain 2 was injected in forearm origin in order to block median proximal nerve in both forelegs. The nerves conduction study (NCS) was recorded before and after lidocain injection, plus 30 min and once again 1 h after calcium gloconate 10, dextrose 50, citric acid solution injection. The recorded data were analyzed using Wilcoxon test and using SPSS software (version 11.5) at significant level of 0.05. RESULTS: The NCS of left and right forearms was 1.4 +/- 1.35 mV and 0.48 +/- 0.45 mV. According to the statistical test, there was no significant difference between two groups (P > 0.05). CONCLUSION: Calcium gloconate 10, dextrose 50, citric acid solution did not reverse the effect of anesthetic drugs. Possible reasons were pressure to the nerves, which were caused by drug volume, and low sample size.