The effect of the blood pressure difference of the receiver and donor in kidney transplantation on the outcomes of kidney function

Abstract

Background: As a result of studies, kidney transplantation from a donor with high blood pressure to a receiver with normal blood pressure and kidney transplantation from a donor with normal blood pressure to a patient with high blood pressure may lead to tissue hypo- and hyper-perfusion and finally, effect on the survival of the transplanted kidney. The aim of this study was determining the effect of blood pressure difference between the receiver and donor in kidney transplantation on the outcome of kidney function. Methods: In a cross-sectional study, 30 kidney transplantations were studied. Blood pressure of donor and receiver was measured before the transplantation and with demographic data entered to special checklist. All the patients were followed after 48 hours after the surgery for outcome of kidney transplantation based on creatinine level and urine output. The effect of the difference in blood pressure between the donor and receiver on the survival of transplanted kidney was evaluated. Findings: The mean creatinine level of the receivers with higher and lower blood pressure amounts was 4.15 ± 1.20 and 5.27 ± 1.69 mg/dl, respectively, and the difference between the two groups was statistically significant (P = 0.044). Six hours after the surgery, the mean level of creatinine was 3.84 ± 0.89 and 4.65 ± 1.72 mg/dl in higher and lower blood pressure receivers, respectively with no statistically difference (P = 0.100). The mean level of creatinine, 24 hours after surgery, was 2.54 ± 0.84 and 4.05 ± 2.24 mg/dl in higher and lower blood pressure receivers, respectively, and the difference was not statistically significant (P = 0.180). Conclusion: According to the results of this study, the difference between blood pressure of donor and receiver is one of the important factors on survival of transplanted kidney. Thus, before the transplantation, investigations about the difference between the blood pressure of donor and receiver mast be noticed. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.