Comparative Evaluation of Two Forms of Drugs: Patch & Lotion of Clobetasol, on Recovery Indicators of Aphthous Stomatitis

Abstract

Aim: Recurrent aphthous stomatitis is common worldwide that occurs in mouth. Clobetasol as the high potent corticosteroids is available in different preparation such as lotion, pomade, this topical forms are for dermatologic use and according to histological different between skin and oral mucosa, administration of its mucoadhesive dosage form is necessary. Materials and Method: In this study the efficacy of clobetasol patch with advantaged of penetration potential, targeted retention profile and resistance to mechanical factors of saliva and mouth with clobetasol lotion were examined. This study is a one-blinded placebo-controlled. Cases were chosen from patient of school of dentistry. They were randomly divided into four groups. Patients were asked to apply the given agent to the identified ulcer 3 times a day topically. The pain average recorded by VAS scale. The size of ulcer was recorded on examination day and day 5 by examiner. The data were entered to SPSS version 20 and survival analysis and repeated measured ANOVA analysis was performed to compare the pain and recovery time and test analysis was performed to compare the size of the lesion. Results: Between the 4 forms, clobetasol patch has the most effect on treatment of aphthous so that the clobetasol patch on day 2, clobetasol lotion on day 3, placebo patch on day 5 and placebo lotion on day 6 the pain has relief. The lesion size was significantly reduced only in clobetasol patch group. Conclusions: Clobetasol patch is more effective on healing and pain relief than the other topical form that designed for dermatologic used.