Comparing the effect of induction with propofol, thiopental sodium and etomidate on hemodynamic changes and surgeon satisfaction during suspension laryngoscopy

Abstract

Background: Induction with hypnotic drugs, as well as suspention laryngoscopy, can be coupled with vast changes in hemodynamic indices. This study aimed to analyze the effect of propofol, etomidate and thiopental sodium, as hypnotic drugs, in hemodynamic changes during suspension laryngoscopy. Methods: In this double-blinded study, 75 patients undergoing elective suspension laryngoscopy were divided into three groups of etomidate (0.3 mg/kg), propofol (2.2 mg/kg) and thiopental sodium (5.0 mg/kg). Hemodynamic parameters were measured at 1, 3, 5, 10, and 15 minutes after induction and 3, 5, 15, and 30 minutes after the recovery; surgeon's satisfaction of surgery and the duration of surgery and recovery time were recorded, too. SPSS software was used for data analysis. Findings: There was no statistical differences in term of demographic data, except height (P = 0.014), hempdynamic parameters after induction of anesthesia, the duration of recovery time, the duration of the surgery and the duration of hospitalization. Five patients (20) had an episode of hypotension in etomidate group, one person (4) in propofol group and four patients (16) in thiopental group; statistical analysis did not show differences between the groups (P = 0.270). Conclusion: Our study showed that there was no difference between administration of propofol, etomidate or thiopental sodium in terms of hemodynamic changes, surgeon's satisfaction of anesthesia and surgery duration. Further studies with greater population are required. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.