Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core-shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Abstract

Biodegradable wound dressing of poly glycerol sebacate/poly hydroxy butyrate was fabricated via the coaxial electrospinning process. Simvastatin and ciprofloxacin were loaded in the core and shell of the fibers, respectively. Scanning electron microscopy and transmission electron microscopy images showed a uniform core/shell structure. Introducing drugs into the polymers would cause the dressing samples to become more hydrophilic and degradation to occur faster. Drugs release would face no interventions, in which, approximately 60 of ciprofloxacin was released during the first 24hours. Simvastatin exhibited a slower and controlled release behavior, with its release peak recorded after 2days. The drug-containing samples showed a proper bactericidal activity against both Gram-positive and Gram-negative bacteria. It may be concluded that the drug-laden wound dressing fabricated in this study is capable of releasing the 2 drugs sequentially and that it is the ideal conditions for controlling infections and reducing wound healing duration.