A hybrid method for 3D mosaicing of OCT images of macula and Optic Nerve Head

Abstract

A mosaiced image is the result of merging two or more images with overlapping area in order to generate a high resolution panorama of a large scene. A wide view of Optical Coherence Tomography (OCT) images can help clinicians in diagnosis by enabling simultaneous analysis of different portions of the gathered information. In this paper, we present a novel method for mosaicing of 3D OCT images of macula and Optic Nerve Head (ONH) that is carried out in two phases; registration of OCT projections and mosaicing of B-scans. In the first phase, in order to register the OCT projection images of macula and ONH, their corresponding color fundus image is considered as the main frame and the geometrical features of their curvelet-based extracted vessels are employed for registration. The registration parameters obtained are then applied on all x-y slices of the 3D OCT images of macula and ONH. In the B-scan mosaicing phase, the overlapping areas of corresponding reprojected B-scans are extracted and the best registration model is obtained based on line-by-line matching of corresponding A-scans in overlapping areas. This registration model is then applied to the remaining A-scans of the ONH-based B-scan. The aligned B-scans of macular OCT and OCT images of ONH are finally blended and 3D mosaiced OCT images are obtained. Two criteria are considered for assessment of mosaiced images; the quality of alignment/mosaicing of B-scans and the loss of clinical information from the B-scans after mosaicing. The average grading values of 3.5 +/- 0.74 and 3.63 +/- 0.55 (out of 4) are obtained for the first and second criteria, respectively.