A clinical debate concerning Aminoglycoside resistance genes among Pseudomonas aeruginosa strains

(2018) A clinical debate concerning Aminoglycoside resistance genes among Pseudomonas aeruginosa strains. World Family Medicine. pp. 167-171. ISSN 1839-0188

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Abstract

Introduction: Pseudomonas aeruginosa is a worldwide nosocomial infection that disrupts hospitalized patient's recovery. Use of the proper anti-pseudomonas antibiotic therapy is an expected challenge among health care providers. Methods: This is a cross-sectional in-vitro study which was conducted in Isfahan in 2016-2017. After selection of the patients with P. aeroginusa infection and isolation of bacteria, the presence of AME coding genes such as aac(6')-II and ant(2 '')-I was surveyed by PCR method. Result: From 350 patients with P.aeruginosa infection, 100 samples were obtained. About half of the strains were taken from urine samples and respiratory tract swap. 93 of Pseudomonas aeruginosa strains were resistant to at least one antibiotic. The highest antibiotic resistance was dedicated to Tobramycin and Meropenem. However, all strains were sensitive to Colistin. In regard to AME genome, 13 specimens had ant(2 '')-I and 4 strains had aac(6')-II genes. aac(6')-II gene caused 75 resistance to Amikacin, Tobramycin, and Gentamycin while ant(2 '')-I gene posed Tobramycin and Gentamycin resistance. Conclusion: Overall, there was a high resistance ratio to various aminoglycosides, B-lactams, and fluoroquinolones isolated from infected patients. Less than 20 of strains demonstrated AME genes of aac(6')-II and ant(2 '')-1.

Item Type: Article
Keywords: pseudomonas aeruginosa aminoglycoside antibiotic resistance nosocomial infection prevalence
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center
Nosocomial Infection Research Center
Page Range: pp. 167-171
Journal or Publication Title: World Family Medicine
Journal Index: ISI
Volume: 16
Number: 3
Identification Number: https://doi.org/10.5742/Mewfm.2018.93327
ISSN: 1839-0188
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/6852

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