(2018) Isolation of dioscin-related steroidal saponin from the bulbs of Allium paradoxum L. with leishmanicidal activity. Research in Pharmaceutical Sciences. pp. 469-475. ISSN 1735-5362
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Abstract
Alliums are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. Allium paradoxum L. is a common edible vegetable in north regions of Iran, especially in Mazandaran province, where it is named "Alezi" and considerably used as a raw vegetable, to make dishes, and as a medicinal plant. Phytochemical investigation of chloroform-methanol extract of the plant resulted in the isolation and identification of a dioscin related steroidal saponin, using comprehensive spectroscopic methods including 1D and 2D NMR, its chemical structure was determined as (25R)-spirost-5-en-3b-ol, 3-O-alpha-rhamnopyranosyl-(1 -> 4)-alpha-rhamnopyranosyl-(1 -> 4)-a-rhamnopyranosyl-(1 -> 2)-glucopyranoside. Investigation of in vitro antileishmanial activity of the isolated compound, in 10 and 50 mu g/mL concentrations, exhibited significant leishmanicidal effects (P < 0.001) against the promastigotes of Leishmania major. The results established a valuable basis for further studies about A. paradoxum and antiparasitic activity of steroidal saponins.
Item Type: | Article |
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Keywords: | allium paradoxum leishmania saponins structure elucidation dioscorea rats mice |
Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacognosy Isfahan Pharmaceutical Sciences Research center |
Page Range: | pp. 469-475 |
Journal or Publication Title: | Research in Pharmaceutical Sciences |
Journal Index: | ISI |
Volume: | 13 |
Number: | 5 |
Identification Number: | https://doi.org/10.4103/1735-5362.236875 |
ISSN: | 1735-5362 |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/6880 |
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