Isolation of dioscin-related steroidal saponin from the bulbs of Allium paradoxum L. with leishmanicidal activity

(2018) Isolation of dioscin-related steroidal saponin from the bulbs of Allium paradoxum L. with leishmanicidal activity. Research in Pharmaceutical Sciences. pp. 469-475. ISSN 1735-5362

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Abstract

Alliums are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. Allium paradoxum L. is a common edible vegetable in north regions of Iran, especially in Mazandaran province, where it is named "Alezi" and considerably used as a raw vegetable, to make dishes, and as a medicinal plant. Phytochemical investigation of chloroform-methanol extract of the plant resulted in the isolation and identification of a dioscin related steroidal saponin, using comprehensive spectroscopic methods including 1D and 2D NMR, its chemical structure was determined as (25R)-spirost-5-en-3b-ol, 3-O-alpha-rhamnopyranosyl-(1 -> 4)-alpha-rhamnopyranosyl-(1 -> 4)-a-rhamnopyranosyl-(1 -> 2)-glucopyranoside. Investigation of in vitro antileishmanial activity of the isolated compound, in 10 and 50 mu g/mL concentrations, exhibited significant leishmanicidal effects (P < 0.001) against the promastigotes of Leishmania major. The results established a valuable basis for further studies about A. paradoxum and antiparasitic activity of steroidal saponins.

Item Type: Article
Keywords: allium paradoxum leishmania saponins structure elucidation dioscorea rats mice
Divisions: Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacognosy
Isfahan Pharmaceutical Sciences Research center
Page Range: pp. 469-475
Journal or Publication Title: Research in Pharmaceutical Sciences
Journal Index: ISI
Volume: 13
Number: 5
Identification Number: https://doi.org/10.4103/1735-5362.236875
ISSN: 1735-5362
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/6880

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