Lack of Evidence of the Role of APOA5 3'UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome

(2018) Lack of Evidence of the Role of APOA5 3'UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome. Diabetes & Metabolism Journal. pp. 74-81. ISSN 2233-6079

Full text not available from this repository.

Abstract

Background: Metabolic syndrome (MetS) is a complex and multifactorial disorder characterized by insulin resistance, dyslipidaemia, hyperglycemia, abdominal obesity, and elevated blood pressure. The apolipoprotein A5 (APOA5) gene variants have been reported to correlate with two major components of MetS, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglyceride. In the present study, we explored the associations between five single nucleotide polymorphisms (SNPs) of APOA5 gene and the MetS risk. Methods: In a case-control design, 120 Iranian children and adolescents with/without MetS were genotyped by polymerase chain reaction-sequencing for these SNPs. Then, we investigated the association of SNPs, individually or in haplotype constructs, with MetS risk. Results: The rs34089864 variant and H1 haplotype (harboring the two major alleles of rs619054 and rs34089864) were associated with HDL-C levels. However, there was no significant association between different haplotypes/individual SNPs and MetS risk. Conclusion: These results presented no association of APOA5 3'UTR SNPs with MetS. Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group.

Item Type: Article
Keywords: apolipoprotein a-v haplotypes metabolic syndrome mir-ts-snp coronary-artery-disease microrna target sites apolipoprotein a-v linking polymorphisms polymirts database complex traits risk gene triglyceride association
Divisions: Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Research Institute for Primordial Prevention of Non-communicable Disease > Child Growth and Development Research Center
Research Institute for Primordial Prevention of Non-communicable Disease > Pediatric Inherited Diseases Research Center
Page Range: pp. 74-81
Journal or Publication Title: Diabetes & Metabolism Journal
Journal Index: ISI
Volume: 42
Number: 1
Identification Number: https://doi.org/10.4093/dmj.2018.42.1.74
ISSN: 2233-6079
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/6924

Actions (login required)

View Item View Item