Neuromyelitis optica spectrum disease characteristics in Isfahan, Iran: A cross-sectional study

(2017) Neuromyelitis optica spectrum disease characteristics in Isfahan, Iran: A cross-sectional study. Journal of Research in Medical Sciences. ISSN 1735-1995

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Abstract

Background: Neuromyelitis optica spectrum disease (NMOSD) is a severe autoimmune demyelinating disorder of the central nervous system that throughout epidemiological data, it has not been completely determined. The aim of this study was to assess characteristics of NMOSD patients in Isfahan as one of the most prevalent cities for multiple sclerosis in Iran. Materials and Mehods: Forty-five patients diagnosed as neuromyelitis optica (NMO) disease through 5 years enrolled in this study. Demographics and characteristics of disease such as Expanded Disability Status Scale (EDSS) score, disease duration, clinical symptoms, laboratory data, and magnetic resonance imaging findings (including T1, T2, and flair protocols) were recorded. NMO-immunoglobulin G serology assay was done in all of the patients by ELISA test. Results: Female to male ratio was 5.4:1. The mean age of disease onset was 29.8 +/- 11.2 years. NMO antibody was positive in 24.4 of patients. The presenting symptoms were optic neuritis (55.5), transverse myelitis (40), and brainstem symptoms (4.5). The interval between the first and second attack was 19.28 +/- 31.27 months (range: 1 month to 17 years). The mean EDSS score of the patients was 2.8 +/- 2.25. Frequency of long-extending cervical plaque was higher among men than women (85.7 vs. 57.9). Conclusion: Based on this study, the mean age of NMOSD onset among Isfahan population was considerably lower than other studies, and there was higher frequency of long-extending cervical lesion among male patients which needs more consideration in further studies.

Item Type: Article
Keywords: demographics devic's syndrome iran neuromyelitis optic multiple-sclerosis clinical-features devics-syndrome multicenter manifestations diagnosis
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Neurology
Faculty of Medicine > Student Research Committee
Other
Journal or Publication Title: Journal of Research in Medical Sciences
Journal Index: ISI
Volume: 22
Identification Number: Artn 41 10.4103/1735-1995.202142
ISSN: 1735-1995
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/712

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