An experimental rat model of hilar splenic vessel ligation versus splenectomy for spleen trauma

(2018) An experimental rat model of hilar splenic vessel ligation versus splenectomy for spleen trauma. International Journal of Burns and Trauma. pp. 117-125. ISSN 2160-2026

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Abstract

Background: The most prevalent method of treating splenic injury is by splenectomy. This method is followed by postoperative complications. Therefore, less invasive procedures such as splenic angioembolization are introduced. This technique needs appropriate training, a high-tech setting and could be followed by complications. Thus, not all surgeons agree to do this procedure. Splenic hilar ligation of main vessels is a non-invasive procedure which has similarities to a splenectomy with unknown results. Objectives: We aim to evaluate and compare splenectomy and hilar ligation. Methods: Thirty rats were divided into splenectomy and splenic hilar ligation groups. An identical grade 3-spleen injury was performed on all rats. After 6 weeks blood samples were obtained and hematologic and immunologic aspects were measured in their serum. Giemsa stained peripheral blood smears were obtained from the ligation group. Results: Comparing the above-mentioned variables before and after the surgery in each groups showed statistical significance in all aspects except IgM, C4 and platelets levels in ligation group (P value: 0.213, 0.059 and 0.649 respectively). Analysis revealed significant deference in postoperative WBC, IgM and C4 levels between splenectomy and ligation group (P value: < 0.001, < 0.001 and 0.026 respectively). Conclusion: Splenic hilar ligation of main vessels is an easy way of treating splenic injury in hemodynamically stable patients with less postoperative complications. Therefore, it can be performed by all surgeons in all kind of medical centers. Spleen remains viable and continues its role although some aspects of its function become interrupted.

Item Type: Article
Keywords: splenectomy spleen therapeutic embolization animal experimentation ligation nonoperative management artery embolization adults blunt injuries preservation salvage experience
Divisions: Faculty of Medicine > Department of Basic Science > Department of Medical Physics
Faculty of Medicine > Departments of Clinical Sciences > Department of Surgery
Page Range: pp. 117-125
Journal or Publication Title: International Journal of Burns and Trauma
Journal Index: ISI
Volume: 8
Number: 5
ISSN: 2160-2026
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/7423

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