Association of high level of Hs-CRP with in-stent restenosis: A case-control study

Abstract

BACKGROUND: In-stent restenosis (ISR) is one adverse outcome of coronary stent implantation. Although using drug-eluting stents has reduced the rate of ISR, it remains a major problem. Here, we have investigated the relationship between several patient characteristics including serum high sensitive C-reactive protein (hs-CRP) and ISR. METHODS: This was a case-control study comprising 104 individuals with ISR and 202 patients without. Baseline characteristics were collected using a questionnaire. Fasting blood glucose (FBG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and serum high sensitivity C-reactive protein (hs-CRP) were measured using commercial kits on an auto-analyzer. Data were analyzed using SPSS software and a p value</=0.05 was considered significant. RESULTS: Diabetes mellitus (p<0.001), stent type (p=0.005), serum hs-CRP (p=0.006), FBG (p=0.038) and serum TG (p=0.039) were significantly associated with ISR. The association between hs-CRP and ISR remained significant after adjustment for stent type and DM. For patients with a serum hs-CRP <2.64mg/dL, ISR was only associated with diabetes mellitus (p=0.016); while for individuals with a serum hs-CRP >/=2.64mg/dL, ISR was also associated with the presence of diabetes mellitus, serum triglycerides and stent type. CONCLUSION: Higher levels of serum hs-CRP were significantly associated with the occurrence of ISR.