What are the Predictive Factors for the Treatment Outcomes in Multi Drug Poisoning Including Antidepressants/Antipsychotic Drugs?

(2018) What are the Predictive Factors for the Treatment Outcomes in Multi Drug Poisoning Including Antidepressants/Antipsychotic Drugs? Adv Biomed Res. p. 136. ISSN 2277-9175 (Print) 2277-9175 (Linking)

Full text not available from this repository.

Abstract

Background: There have been studies on the outcome of acute intoxication with antidepressants or antipsychotics. We performed outcome prediction analysis in acute poisoning patients with antidepressants/antipsychotics with or without combination with other drugs. Materials and Methods: A cross-sectional study was performed in Khorshid (PBUH) University Hospital affiliated with Isfahan University of Medical Sciences from March 2016 to May 2017. Patients with acute poisoning ingested antidepressants and antipsychotics with or without other drugs were included in the study. The outcome was categorized as survived without complications and complications/death. Binary regression analysis was performed for outcome prediction. Results: The data from 239 patients were analyzed. Most of the patients were female (68.2), 5.9 of patients admitted to the Intensive Care Unit. About 94.99 of patients survived without complications. There was a significant difference between patients with and without complications with respect to the level of consciousness, hypotension, seizure, electrocardiography findings, pulse rate after 24 hours (h) of admission, and need to endotracheal intubation (P < 0.0001). Binary logistic regression analysis showed admission level of consciousness (stupor/coma) (odds ratio OR =8.07; P = 0,005), hypotension (OR = 12.16; P = 0.001), seizure (OR = 11.15; P = 0.009), tachycardia after 24 h of admission (OR = 22.50; P = 0.003), and need for endotracheal intubation (OR = 10.47; P = 0.002) were determinant factors in outcome prediction. Conclusions: Stupor/coma and hypotension were the predictive factors for outcome. Patients with seizure and tachycardia after 24 h of admission; and those intubated and received mechanical ventilation had a higher chance of complications.

Item Type: Article
Keywords: Antidepressant antipsychotic complication outcome poisoning
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Anesthesiology
Faculty of Medicine > Departments of Clinical Sciences > Department of Clinical Toxicology
Faculty of Medicine > Departments of Clinical Sciences > Department of Social Medicine
Page Range: p. 136
Journal or Publication Title: Adv Biomed Res
Journal Index: Pubmed
Volume: 7
Identification Number: https://doi.org/10.4103/abr.abr₁₃₂₁₈
ISSN: 2277-9175 (Print) 2277-9175 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/7666

Actions (login required)

View Item View Item