Effects of Isolation and Social Subchronic Stresses on Food Intake and Levels of Leptin, Ghrelin, and Glucose in Male Rats

(2018) Effects of Isolation and Social Subchronic Stresses on Food Intake and Levels of Leptin, Ghrelin, and Glucose in Male Rats. Adv Biomed Res. p. 118. ISSN 2277-9175 (Print) 2277-9175 (Linking)

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Abstract

Background: Exposure to psychological stresses can be a reason for obesity. Therefore, identifying the effective nutritional mechanisms such as feeding markers is of high necessity for the psychological stress conditions. Hence, the present study investigates the effects of subchronic isolation and social stresses on food intake, body weight differences (BWD), and levels of leptin, ghrelin, and glucose in rats. Materials and Methods: Eighteen male rats were randomly allocated into three groups: control (Co), isolation stress (IS), and social stress (SS) groups. Rats were under stresses for 7 days. The food intake (for three continuous hours after 16-18 h of food deprivation), BWD, levels of ghrelin, leptin, and glucose were measured. Results: The results showed that the food intake significantly (P < 0.05) reduced during the 1(st) h in the SS group compared to the Co group. At the 2(nd) h, the food intake significantly (P < 0.001 and P < 0.01, respectively) decreased in the IS group compared to the Co and SS groups. The cumulative food intake and body weight were significantly (P < 0.05) reduced in the IS group compared to the Co group. The serum ghrelin level significantly reduced in the IS group compared to the Co group. Conclusions: The subchronic psychological stresses led to a reduction in food intake by the reduction of serum ghrelin levels. It seems that ghrelin might have a more fundamental role in the food intake with respect to the leptin and glucose levels in subchronic stress condition. Furthermore, the decreased body weight justified the reduction of food intake, particularly in subchronic isolation stress.

Item Type: Article
Keywords: Food intake ghrelin glucose isolation stress leptin social stress
Divisions: Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: p. 118
Journal or Publication Title: Adv Biomed Res
Journal Index: Pubmed
Volume: 7
Identification Number: https://doi.org/10.4103/abr.abr₂₈₁₈
ISSN: 2277-9175 (Print) 2277-9175 (Linking)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/7726

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