The effect of two different prophylactic doses of magnesium sulfate on reduction of succinylcholine complications in elective cesarean section under general anesthesia in comparison with control group

Abstract

Background: This study aimed to evaluate the effect of two prophylactic different doses of magnesium sulfate on succinylcholine complications in elective cesarean section under general anesthesia in comparison with control group. Methods: In a clinical trial study, 165 pregnant women candidates for cesarean section were divided into three groups of 55, receiving 30 or 40 mg/kg magnesium sulfate, or normal saline (placebo) under general anesthesia. Hemodynamic parameters were measured and recorded during recovery and operation, as well as the serum levels of magnesium, potassium, and creatine phosphokinase (CPK) before receiving magnesium sulfate, and 20 minutes after induction of anesthesia. Moreover, myoglobinuria was measured and recorded. Findings: Specific reductions were found in moderate blood pressure and heart rate at third minute after laryngoscopy in groups receiving magnesium sulfate (P < 0.001 for both). Fasciculation was observed in 53.6 of the patients receiving magnesium sulfate, and 87.2 of the patients in the placebo group. The fasciculation observed in groups receiving magnesium sulfate was classified as mild. Conclusion: Administration of magnesium sulfate 30 mg/kg as well as 40 mg/kg before cesarean section under general anesthesia can effectively reduce the severity of fasciculation and myalgia, and the effects of succinylcholine on rapid induction of anesthesia in pregnant women. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.