Evaluation of clinical manifestations, complications, and disease course in children admitted with Henoch-Schonlein purpura in Imam Hossain hospital, Isfahan, Iran, during 2011-2014

Abstract

Background: Henoch-Schonlein purpura (HSP) is a common childhood systemic vasculitis with clinical characteristics of cutaneous palpable purpura, arthralgia/arthritis, abdominal pain, and renal involvement. The diagnosis of Henoch-Schonlein purpura is usually based upon clinical manifestations of the disease; but, clinical manifestations are different in various countries. We aimed to find the frequency of clinical manifestations of this disease in Iran. Methods: A retrospective study was performed on children discharged with diagnosis of Henoch-Schonlein purpura from Imam Hossain Children's Hospital, Isfahan, Iran, during 2011 to 2014. Symptoms, signs, laboratory data, treatment, and outcomes were collected via reviewing medical charts. Findings: The sample consisted of 106 children. There was a male predominance with male-to-female ratios of 2.1:1 and the mean age was 5.7 ± 0.5 years. Clinical manifestation of purpura was present in 100, arthritis/arthralgia in 76, abdominal pain in 62, fever in 30, renal involvement in 29, gastrointestinal tract bleeding (GIB) in 22, scrotal edema in 11, and intussusception in 1.8 of the cases. The most frequent laboratory abnormalities consisted of high erythrocyte sedimentation rate (ESR) in 100, and C-reactive protein (CRP) in 58 of the cases. Conclusion: Our findings indicate that there are higher incidences of abdominal pain, gastrointestinal tract bleeding, and intussusception in our sample compared to other studies. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.