Evaluation and comparison of the effects of propofol, dexamethasone, and ondonestrone in the prevention of complications during and after cataract surgery

Abstract

Background: One of the complications after cataract surgery is pruritus. In this study for the first time, the effects of intravenous injection of ondansetron, propofol, and dexamethasone on reducing the incidence of pruritus after cataract surgery were compared with the control group. Methods: In this clinical trial study, patients were randomly divided into four groups of dexamethasone, ondansetron, propofol, and normal saline for intravenous infusion. After entering the recovery for up to 6 hours, the patient was asked about itching, nausea, and vomiting. Information was compared between the four groups. Findings: The level of pruritus around the eyes during 0 to 1 hour after the surgery was significantly lower in the ondansetron and dexamethasone groups than others (P < 0.050). There was no significant difference between the groups regarding the level of pruritus around the eyes during 1 to 2 and 2 to 6 hours after the surgery (P < 0.050 for all). Conclusion: Propofol plays a major role in reducing postoperative nausea and vomiting. Ondansetron is effective in reducing nausea and vomiting and itching after the surgery. Dexamethasone is also effective in reducing pruritus around the eyes after the surgery. It is recommended to do more researches with more samples in addition to eliminating the limitations. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.