The relationship between serum level of high-sensitivity C-reactive protein (hs-CRP) and residual renal function in patients under peritoneal dialysis during one year

Abstract

Background: Residual renal function helps the part of solute clearance in patients under peritoneal dialysis. Some studies showed that decline in renal function maybe associate with production of inflammatory mediators in these patients. The aim of this study was to assess the relationship between serum level of highsensitive C-reactive protein (hs-CRP) and residual renal function in patients under peritoneal dialysis during one year. Methods: In this prospective study, residual renal function estimated by determination of renal creatinine clearance (R Clcr) and renal Kt/V (a number used to quantify hemodialysis and peritoneal treatment adequacy). Serum level of hs-CRP and renal creatinine clearance and renal Kt/V was measured at baseline, and 6 and 12 month after start of study and changes of these parameters during the year and their relationship with together were studied. Findings: Among 96 patients, we did not lose any patients for final analysis. Mean serum level of hs-CRP at baseline, and 6 and 12 months later was 3.585, 4.205, and 4.738 mg/l, respectively. Mean renal creatinine clearance was 58.186, 37.054, 36.299 ml/minute at baseline, and 6 and 12 months later, respectively. Mean renal Kt/V at baseline, and 6 and 12 months later was 3.627, 1.813 and 0.841, respectively. Conclusion: Finally, our statistical analysis showed the negative relationship between changes of serum level of hs-CRP and residual renal function in patients under peritoneal dialysis during one year; but, this relationship was not significant. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.