The Effect of Creatine Supplementation with Resistance Training on the Levels of Renin and Aldosterone in Wistar Rats

Abstract

Objective: The aim of the present study was to compare the effect of creatine 2 and 5 supplementation with resistance training on the levels of renin and aldosterone Methods: The 60 Wistar rats were randomly assigned to six groups (resistance training, creatine 2 and creatine 5, resistance training plus creatine 2 supplementation, resistance training plus creatine 5 supplementation, control). The training included 8 weeks and 5 sessions a week climbing a 1-meter ladder with 26 rungs with 2-cm distances. The One - way analysis of variance (ANOVA) test was used for comparing the variables between groups and LSD test was used for pair-wise comparisons. Results: There was no significant difference between mean differences of renin level in different groups compared to the control group. Butthere was a significant difference between mean difference of aldosterone level in creatine 5 groups and control group as well as between resistance training plus creatine 2 and creatine 5 groups (p < 0.05). Also, there was significant difference between mean difference of aldosterone level in resistance training and creatine 5 groups (p < 0.05). Conclusion: As regard to result of the present study consumption of creatine 2 and 5 supplementation may be useful and safe for human so further studies is suggested.