Analysis of polymorphism and expression profile of ASIC1 and IL-6 genes in patients with gastric cancer

(2018) Analysis of polymorphism and expression profile of ASIC1 and IL-6 genes in patients with gastric cancer. Asian Pacific Journal of Cancer Prevention. pp. 3451-3455. ISSN 15137368 (ISSN)

Full text not available from this repository.

Abstract

Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of gastric cancer. Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of the ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls. We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Results: Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p < 0.001). © 2018, Asian Pacific Organization for Cancer Prevention.

Item Type: Article
Keywords: ASIC1 Expression Gastric cancer IL-6 Polymorphism
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Radiooncology
Page Range: pp. 3451-3455
Journal or Publication Title: Asian Pacific Journal of Cancer Prevention
Journal Index: Scopus
Volume: 19
Number: 12
Identification Number: https://doi.org/10.31557/APJCP.2018.19.12.3451
ISSN: 15137368 (ISSN)
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/9277

Actions (login required)

View Item View Item