(2018) Analysis of polymorphism and expression profile of ASIC1 and IL-6 genes in patients with gastric cancer. Asian Pacific Journal of Cancer Prevention. pp. 3451-3455. ISSN 15137368 (ISSN)
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Abstract
Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of gastric cancer. Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of the ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls. We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Results: Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p < 0.001). © 2018, Asian Pacific Organization for Cancer Prevention.
Item Type: | Article |
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Keywords: | ASIC1 Expression Gastric cancer IL-6 Polymorphism |
Divisions: | Faculty of Medicine > Departments of Clinical Sciences > Department of Radiooncology |
Page Range: | pp. 3451-3455 |
Journal or Publication Title: | Asian Pacific Journal of Cancer Prevention |
Journal Index: | Scopus |
Volume: | 19 |
Number: | 12 |
Identification Number: | https://doi.org/10.31557/APJCP.2018.19.12.3451 |
ISSN: | 15137368 (ISSN) |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/9277 |
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