A comparison of dual triggering (by administration of GnRH agonist plus HCG) versus HCG alone in poor ovarian responders in ART outcomes

Abstract

Background: The use of dual triggering in high and normal responders accompanied with better IVF cycles outcomes. Also, it has been suggested that dual triggering in poor responders can accompanied with better results. Objective: The aim of present study was to evaluate whether the Dual trigger, can improve oocyte maturation in poor responder patients based on Bologna criteria and their ART outcomes. Materials and methods: All poor ovarian responder's patients underwent GnRH antagonist controlled ovarian hyperstimulation protocols in ART cycles. The participants' randomizations were done and patients divided into two groups. In the first group, final oocyte maturation was done by 6500 I.U.HCG alone. In the second group triggering was done with coadministration of 6500 I.U.HCG plus 0.2 mg triptorelin simultaneous (dual trigger). Oocytes retrieval was performed 36 h after triggering through transvaginal ultrasound guided. Routine IVF/ICSI was performed as appropriate. Results: Number of retrieved oocytes, number of mature oocytes (MII), number of fertilized oocytes (2PN), number of embryos formation, number of transferred embryos and embryos quality have not significant differences between two groups (p > 0.05). Also, fertilization and implantation rate, chemical and clinical pregnancy did not differ between groups. Conclusion: Dual triggering for final oocyte maturation in poor ovarian responders did not improve the number of mature oocytes (MII) and other ART cycle results. (C) 2018 Middle East Fertility Society. Production and hosting by Elsevier B.V.