Evaluation of structural, mechanical, and cellular behavior of electrospun poly-3-hydroxybutyrate scaffolds loaded with glucosamine sulfate to develop cartilage tissue engineering

(2017) Evaluation of structural, mechanical, and cellular behavior of electrospun poly-3-hydroxybutyrate scaffolds loaded with glucosamine sulfate to develop cartilage tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. pp. 589-602. ISSN 0091-4037

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Abstract

Considering the role of glucosamine sulfate (GS) in the biosynthetic pathways of chondrocytes, an attempt was made to design an electrospun poly-3-hydroxybutyrate (PHB) scaffold loaded with GS to develop cartilage tissue engineering. The study was initiated using the optimal electrospun scaffold conditions for the synthesis of PHB/GS. The resulting scaffolds have shown excellent pore architectures and mechanical behavior compared to pure PHB. UV spectrophotometric analysis, for the evaluation of the GS release behavior, showed zero-order kinetics release. In vitro results indicated excellent cell viability, cell adhesion, and cell penetration of PHB/GS scaffolds compared to pure PHB. GRAPHICS .

Item Type: Article
Keywords: cartilage tissue engineering chondrocyte electrospun scaffold glucosamine sulfate poly-3-hydroxybutyrate articular-cartilage drug-delivery stem-cells biomedical applications human osteoarthritis raw-materials dosage forms amino-sugars in-vitro chondrocytes
Divisions: Faculty of Medicine > Department of Basic Science > Department of Anatomical Sciences
School of Advanced Technologies in Medicine > Department of Biomaterials, Nanotechnology and Tissue Engineering
Page Range: pp. 589-602
Journal or Publication Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Journal Index: ISI
Volume: 66
Number: 12
Identification Number: https://doi.org/10.1080/00914037.2016.1252353
ISSN: 0091-4037
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/951

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