(2017) Evaluation of structural, mechanical, and cellular behavior of electrospun poly-3-hydroxybutyrate scaffolds loaded with glucosamine sulfate to develop cartilage tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. pp. 589-602. ISSN 0091-4037
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Abstract
Considering the role of glucosamine sulfate (GS) in the biosynthetic pathways of chondrocytes, an attempt was made to design an electrospun poly-3-hydroxybutyrate (PHB) scaffold loaded with GS to develop cartilage tissue engineering. The study was initiated using the optimal electrospun scaffold conditions for the synthesis of PHB/GS. The resulting scaffolds have shown excellent pore architectures and mechanical behavior compared to pure PHB. UV spectrophotometric analysis, for the evaluation of the GS release behavior, showed zero-order kinetics release. In vitro results indicated excellent cell viability, cell adhesion, and cell penetration of PHB/GS scaffolds compared to pure PHB. GRAPHICS .
Item Type: | Article |
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Keywords: | cartilage tissue engineering chondrocyte electrospun scaffold glucosamine sulfate poly-3-hydroxybutyrate articular-cartilage drug-delivery stem-cells biomedical applications human osteoarthritis raw-materials dosage forms amino-sugars in-vitro chondrocytes |
Divisions: | Faculty of Medicine > Department of Basic Science > Department of Anatomical Sciences School of Advanced Technologies in Medicine > Department of Biomaterials, Nanotechnology and Tissue Engineering |
Page Range: | pp. 589-602 |
Journal or Publication Title: | International Journal of Polymeric Materials and Polymeric Biomaterials |
Journal Index: | ISI |
Volume: | 66 |
Number: | 12 |
Identification Number: | https://doi.org/10.1080/00914037.2016.1252353 |
ISSN: | 0091-4037 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.mui.ac.ir/id/eprint/951 |
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