Primary Ovarian Carcinoma Associated with Ovulation Induction: A Case Report

Abstract

Introduction: The relationship between ovulation induction and ovarian cancer is an important issue in gynecology. Case Presentation: The studied patient was a 32-year-old G1P1 woman with abdominal pain who was diagnosed with a large ovarian cyst during ovulation induction, which could possibly raise the risk of ovarian torsion. She had a 2-year secondary infertility and had received three cycles of ovulation induction with letrozole 6 months earlier. An emergency laparoscopy showed large complex ovarian cysts without torsion. We then performed a cystectomy. Based on the pathology report revealing a primary ovarian cystadenocarcinoma, the patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and retroperitoneal lymphadenectomy. Conclusions: The emergence of a suspected ovarian cyst during letrozole-induced ovulation is of great importance and needs to be investigated.