High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy

(2018) High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy. NeuroImmunoModulation. pp. 80-88. ISSN 1021-7401

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Abstract

Objectives: Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. Methods: Twelve pre- and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs. Results: The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (p < 0.05), and after TE Tc22 cells significantly decreased compared to pre-TE (p < 0.05). The frequency of Th22 cells in pre-TE MG patients was not significantly different from HCs, but after TE Th22 cells were significantly decreased compared to pre-TE (p < 0.05). Conclusion: Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis. (C) 2018 S. Karger AG, Basel

Item Type: Article
Keywords: myasthenia gravis thymectomy th22 cells tc22 cells cd8(+) t-cells acetylcholine-receptor multiple-sclerosis circulating th22 interleukin 22 th17 antibody immune thymus inflammation
Divisions: Faculty of Health > Department of Epidemiology and Biostatistics
Faculty of Medicine > Department of Basic Science > Immunology Department
Isfahan Neurosciences Research Center
Other
Page Range: pp. 80-88
Journal or Publication Title: NeuroImmunoModulation
Journal Index: ISI
Volume: 25
Number: 2
Identification Number: https://doi.org/10.1159/000490855
ISSN: 1021-7401
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/9726

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