(2018) High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy. NeuroImmunoModulation. pp. 80-88. ISSN 1021-7401
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Abstract
Objectives: Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. Methods: Twelve pre- and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs. Results: The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (p < 0.05), and after TE Tc22 cells significantly decreased compared to pre-TE (p < 0.05). The frequency of Th22 cells in pre-TE MG patients was not significantly different from HCs, but after TE Th22 cells were significantly decreased compared to pre-TE (p < 0.05). Conclusion: Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis. (C) 2018 S. Karger AG, Basel
Item Type: | Article |
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Keywords: | myasthenia gravis thymectomy th22 cells tc22 cells cd8(+) t-cells acetylcholine-receptor multiple-sclerosis circulating th22 interleukin 22 th17 antibody immune thymus inflammation |
Divisions: | Faculty of Health > Department of Epidemiology and Biostatistics Faculty of Medicine > Department of Basic Science > Immunology Department Isfahan Neurosciences Research Center Other |
Page Range: | pp. 80-88 |
Journal or Publication Title: | NeuroImmunoModulation |
Journal Index: | ISI |
Volume: | 25 |
Number: | 2 |
Identification Number: | https://doi.org/10.1159/000490855 |
ISSN: | 1021-7401 |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/9726 |
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