(2018) Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction after Thymectomy May Be Related to Disease Progression in Myasthenia Gravis. NeuroImmunoModulation. pp. 264-270. ISSN 10217401 (ISSN)
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Abstract
Objective: Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the neuromuscular junction. The thymus has an important role in the pathogenesis of MG because most patients have thymic pathology, and thymectomy (TE) can reduce the severity of the disease. Methods: In this study, the frequency of Th17 and Tc17 cells was studied in 12 MG patients (pre-TE and 6 months post-TE) and in 12 healthy controls (HC). Results: The frequency of Tc17 cells in the pre-TE patients was significantly higher than in the HC (p < 0.05), and after TE, these cells had significantly decreased compared to before TE (p < 0.05). The frequency of Th17 cells in pre-TE patients was significantly higher than in the HC (p < 0.05), and after TE, these cells had significantly decreased compared to before TE (p < 0.05). Conclusion: Our findings indicated a possible role of Tc17 and Th17 in MG pathogenesis. © 2018 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Keywords: | Myasthenia gravis Tc17 Th17 Thymectomy interleukin 17 adult Article CD8+ T lymphocyte clinical article controlled study disease exacerbation female human human cell human tissue immunopathogenesis in vitro study lymphocyte count lymphocyte function male postoperative period preoperative period priority journal T lymphocyte subpopulation tc17 cell Th17 cell |
| Divisions: | Faculty of Health > Department of Epidemiology and Biostatistics Faculty of Medicine > Department of Basic Science > Immunology Department Other |
| Page Range: | pp. 264-270 |
| Journal or Publication Title: | NeuroImmunoModulation |
| Journal Index: | Scopus |
| Volume: | 24 |
| Number: | 4-5 |
| Identification Number: | https://doi.org/10.1159/000486037 |
| ISSN: | 10217401 (ISSN) |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/9748 |
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