(2019) Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome. Iranian Journal of Child Neurology. pp. 37-44. ISSN 1735-4668
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Abstract
Objectives Cyclic vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder with no certain treatment. We aimed to compare the efficacy of amitriptyline and topiramate on prophylactic therapy of CVS. Materials and Methods Thisrandomizedclinicaltrial(registrationnumber: IRCT2015102316844N2) was conducted during 2016 in Isfahan, central Iran. The inclusion criteria were CVS patients (based on Rome III) aging 3-15 yr with normal physical examination, no metabolic disorder, and no gastrointestinal obstruction or renal impairment. Recruited patients were divided into two groups of amitriptyline (1 mg/kg/d) and topiramate (1-2 mg/kg/d) and were followed for 3-months. The outcome was evaluated by comparing severity of attacks (monthly frequency and duration of attacks) before and after intervention. Results Thirty-six children entered each group and two patients left the amitriptyline group. Patients and disease characteristics were similar between groups before intervention (P>0.05). The frequency of attacks (standard deviation) after intervention in amitriptyline and topiramate group was 0.91 (0.40) and 1.07 (0.55), respectively (P=0.368) and the duration of attacks (SD) after intervention were 3.43 (2.46) and 4.90 (3.03), respectively (P=0.017). Twenty-three patients (68) in amitriptyline group and 14 patients (39) in topiramate group stopped having attacks after intervention (P=0.016). Conclusion Amitriptyline is a better choice to reduce severity of CVS attacks compared to topiramate, in a short-term evaluation. Studies with longer follow-up are required to investigate these findings in a longer period.
Item Type: | Article |
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Keywords: | amitriptyline topiramate cyclic vomiting syndrome rct prophylaxis children therapy experience management diagnosis adults |
Subjects: | QV Pharmacology |
Divisions: | Research Institute for Primordial Prevention of Non-communicable Disease > Child Growth and Development Research Center |
Page Range: | pp. 37-44 |
Journal or Publication Title: | Iranian Journal of Child Neurology |
Journal Index: | ISI |
Volume: | 13 |
Number: | 1 |
ISSN: | 1735-4668 |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/9936 |
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