Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome

(2019) Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome. Iranian Journal of Child Neurology. pp. 37-44. ISSN 1735-4668

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Abstract

Objectives Cyclic vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder with no certain treatment. We aimed to compare the efficacy of amitriptyline and topiramate on prophylactic therapy of CVS. Materials and Methods Thisrandomizedclinicaltrial(registrationnumber: IRCT2015102316844N2) was conducted during 2016 in Isfahan, central Iran. The inclusion criteria were CVS patients (based on Rome III) aging 3-15 yr with normal physical examination, no metabolic disorder, and no gastrointestinal obstruction or renal impairment. Recruited patients were divided into two groups of amitriptyline (1 mg/kg/d) and topiramate (1-2 mg/kg/d) and were followed for 3-months. The outcome was evaluated by comparing severity of attacks (monthly frequency and duration of attacks) before and after intervention. Results Thirty-six children entered each group and two patients left the amitriptyline group. Patients and disease characteristics were similar between groups before intervention (P>0.05). The frequency of attacks (standard deviation) after intervention in amitriptyline and topiramate group was 0.91 (0.40) and 1.07 (0.55), respectively (P=0.368) and the duration of attacks (SD) after intervention were 3.43 (2.46) and 4.90 (3.03), respectively (P=0.017). Twenty-three patients (68) in amitriptyline group and 14 patients (39) in topiramate group stopped having attacks after intervention (P=0.016). Conclusion Amitriptyline is a better choice to reduce severity of CVS attacks compared to topiramate, in a short-term evaluation. Studies with longer follow-up are required to investigate these findings in a longer period.

Item Type: Article
Keywords: amitriptyline topiramate cyclic vomiting syndrome rct prophylaxis children therapy experience management diagnosis adults
Subjects: QV Pharmacology
Divisions: Research Institute for Primordial Prevention of Non-communicable Disease > Child Growth and Development Research Center
Page Range: pp. 37-44
Journal or Publication Title: Iranian Journal of Child Neurology
Journal Index: ISI
Volume: 13
Number: 1
ISSN: 1735-4668
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/9936

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