(2017) MicroRNA-196a as a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma. Cancer Investigation. pp. 78-84. ISSN 0735-7907
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Abstract
We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p = .002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC. In addition, molecular pathway enrichment analysis of microRNA (miR)-196a determined focal adhesion, spliceosome and p53 signaling pathways as the most relevant pathways with miR-196a targetome.
| Item Type: | Article |
|---|---|
| Keywords: | escc mir-196a biomarker saliva down-regulation expression cancer survival rna adenocarcinoma association prognosis mechanism binding |
| Divisions: | Faculty of Medicine > Departments of Clinical Sciences > Department of Pathology Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmaceutical Biotechnology |
| Page Range: | pp. 78-84 |
| Journal or Publication Title: | Cancer Investigation |
| Journal Index: | ISI |
| Volume: | 35 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.1080/07357907.2016.1254228 |
| ISSN: | 0735-7907 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mui.ac.ir/id/eprint/1011 |
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