Effectiveness of Filgrastim and Polyethylene Glycol-Filgrastim in the Treatment of Postchemotherapy Neutropenia in Children: Phase I Clinical Trial

(2019) Effectiveness of Filgrastim and Polyethylene Glycol-Filgrastim in the Treatment of Postchemotherapy Neutropenia in Children: Phase I Clinical Trial. Indian Journal of Medical and Paediatric Oncology. pp. 101-104. ISSN 0971-5851

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Abstract

Background: One of the most common side effects of chemotherapy in cancer patients is neutropenia that can result in hospitalization. The purpose of this study was to evaluate the efficacy and tolerability of polyethylene glycol (PEG)-filgrastim compared with filgrastim in the recovery of neutropenia. Methods: This study was a Phase I clinical trial conducted among patients with acute lymphoblastic leukemia aged <16 years who were referred to the Ali Asghar Hospital, Tehran, Iran, from April 2012 until October 2013. Eleven patients were selected, and filgrastim and PEG-filgrastim were injected subcutaneously at a dose of 5-10 mu g/kg/day for 7 days and 100 mu g/kg as a single dose, respectively. Absolute neutrophil count (ANC) was checked 7 days after the last injection in the two groups. Results: The mean age of the patients was 8.82 +/- 4.36 years (3-15 years). Six boys (54.5) and five girls (45.5) participated in the study. ANC increase among patients treated with PEG-filgrastim or filgrastim was analyzed separately, and the results showed statistically significant differences between the study groups (P = 0.038). Conclusions: According to the findings, it can be concluded that the PEG-filgrastim is better than filgrastim alone to improve neutropenia induced by chemotherapy in patients with acute lymphoblastic leukemia.

Item Type: Article
Keywords: chemotherapy children filgrastim neutropenia polyethylene glycol-filgrastim colony-stimulating factor chemotherapy pegfilgrastim cancer csf toxicity efficacy
Subjects: WS Pediatrics
Divisions: Other
Page Range: pp. 101-104
Journal or Publication Title: Indian Journal of Medical and Paediatric Oncology
Journal Index: ISI
Volume: 40
Number: 1
Identification Number: https://doi.org/10.4103/ijmpo.ijmpo₁₃₄₁₈
ISSN: 0971-5851
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/10338

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