Co-administration of walnut (Juglans regia) prevents systemic hypertension induced by long-term use of dexamethasone: a promising strategy for steroid consumers

(2017) Co-administration of walnut (Juglans regia) prevents systemic hypertension induced by long-term use of dexamethasone: a promising strategy for steroid consumers. Pharmaceutical Biology. pp. 184-189. ISSN 1388-0209

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Abstract

Context: The long-term consumption of glucocorticoids (GCs) may induce serious adverse effects such as hypertension. There is sufficient evidence related to the benefit of walnuts on the cardiovascular system. Objective: This study assesses the effect of methanol extract of walnut Juglans regia L. (Juglandaceae) on dexamethasone-induced hypertension and the possible mechanisms in Wistar rats. Material and methods: Animals were randomized into control, kernel extract (100 and 200 mg/kg/d, orally), dexamethasone (0.03 mg/kg/d, subcutaneously), dexamethasone+kernel (100 and 200mg/kg/d, separately), and dexamethasone+captopril (25 mg/kg/d, orally) groups. Animals were treated with water, kernel extract or captopril by gavage 4 d before and during 11 d of saline or dexamethasone treatment. On the 16th day, blood pressure (BP) was recorded and blood samples were collected to measure nitric oxide (NO). Animal hearts were frozen for measurement of malondialdehyde (MDA) and glutathione peroxidase (GPX). Results: Dexamethasone increased the diastolic BP and MDA/GPX ratio in comparison with control group (128 +/- 7 vs. 105 +/- 3mmHg, p < 0.05 and 0.2 +/- 0.046 vs. 0.08 +/- 0.02, p < 0.05). Combination of dexamethasone and walnut (200mg/kg) prevented the dexamethasone-induced diastolic hypertension (109 +/- 3 vs. 128 +/- 7mmHg; p < 0.05), increased the GPX level (14.8 +/- 1.46 vs. 5.1 +/- 0.64 unit/mg, p < 0.05), reduced the MDA/GPX ratio (0.16 +/- 0.015 vs. 0.2 +/- 0.046) and improved serum NO level. Conclusion: Similar to captopril, walnut extract normalized dexamethasone-induced hypertension. A part of this beneficial effect apparently involves maintaining balance of the redox system and NO production.

Item Type: Article
Keywords: kernel glucocorticoid redox system oxidative stress blood-pressure endothelial function rats acid oil glucocorticoids injury trial fruit
Divisions: Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: pp. 184-189
Journal or Publication Title: Pharmaceutical Biology
Journal Index: ISI
Volume: 55
Number: 1
Identification Number: https://doi.org/10.1080/13880209.2016.1233570
ISSN: 1388-0209
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mui.ac.ir/id/eprint/1044

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