(2019) Metastatic components in colorectal cancer. Journal of Research in Medical Sciences. p. 7. ISSN 1735-1995
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Abstract
Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs). In this review, we discuss interactions between CSCs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer.
| Item Type: | Article |
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| Keywords: | Cancer stem cells colorectal cancer metastasis tumor microenvironment growth-factor receptor stromal fibroblasts tumor angiogenesis stem-cells expression heterogeneity activation model smad4 General & Internal Medicine |
| Subjects: | WI Digestive System > WI 400-575 Intestines |
| Divisions: | Cardiovascular Research Institute > Applied Physiology Research Center |
| Page Range: | p. 7 |
| Journal or Publication Title: | Journal of Research in Medical Sciences |
| Journal Index: | ISI |
| Volume: | 24 |
| Identification Number: | https://doi.org/10.4103/jrms.JRMS₉₅₇₁₈ |
| ISSN: | 1735-1995 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/11138 |
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