Asian Study of Cerebral Venous Thrombosis

Abstract

Background/Objective: Most of the studies and registries related to cerebral venous thrombosis (CVT) are reported from European countries and the United States. The objective of the present study is to identify risk factors, presentation, and outcome of CVT in Asian patients. Methods: Asian CVT registry is a prospective multinational observational study that included patients (aged > 16 years) with symptomatic CVT. Results: Eight hundred and twelve patients (59 women) from 20 centers in 9 Asian countries were included. Mean age of the patients was 31 years. Motor weakness in limbs was present in 325 (40) patients. One hundred and eighty (22.1) patients had a normal Glasgow coma scale (GCS) at presentation, and another 529 patients (65) had GCS between 11 and 14. The rest (103; 13) had a GCS of less than 10 at presentation. Permanent risk factors were present in 264 (33) patients, transient in 342 (42) patients, both in 43 (5) patients and no risk factors were found in 163 (20) patients. Anemia was present in 51, use of oral contraceptive pills (OCP) was present in 12 women and a hypercoaguable state was present in more than 40 of those tested. One hundred and forty-three cases (18) were in women who were either pregnant (18; 2) or in the puerperium (up to 6 weeks postpartum; N = 125; 15). A total of 86 (10.5) patients were diagnosed with infection in any part of the body. The most common MRI finding was local brain edema or ischemia (53.3) followed by hemorrhage (26.7). Twenty-seven patients (3.3) died during hospital stay. The mRS score at discharge was available for 661 (81) patients. Of these, 577 (87.3) had good functional outcome at discharge. Motor weakness at presentation, GCS of 9 or less and mental status disorder were the strongest independent predictors of mortality at last follow-up among patients with CVT. Conclusions: Important differences were identified as compared to western data including younger age, high frequency of anemia, low use of OCP, and high frequency of hypercoaguable states. Functional outcome at discharge was good.