Super-Resolution of Optical Coherence Tomography Images by Scale Mixture Models

Abstract

In this paper, a new statistical model is proposed for the single image super-resolution of retinal Optical Coherence Tomography (OCT) images. OCT imaging relies on interfero-metry, which explains why OCT images suffer from a high level of noise. Moreover, data subsampling is carried out during the acquisition of OCT A-scans and B-scans. So, it is necessary to utilize effective super-resolution algorithms to reconstruct high-resolution clean OCT images. In this paper, a nonlocal sparse model-based Bayesian framework is proposed for OCT restoration. For this reason, by characterizing nonlocal patches with similar structures, known as a group, the sparse coefficients of each group of OCT images are modeled by the scale mixture models. In this base, the coefficient vector is decomposed into the point-wise product of a random vector and a positive scaling variable. Estimation of the sparse coefficients depends on the proposed distribution for the random vector and scaling variable where the Laplacian random vector and Generalized Extreme-Value (GEV) scale parameter (Laplacian+GEV model) show the best goodness of fit for each group of OCT images. Finally, a new OCT super-resolution method based on this new scale mixture model is introduced, where the maximum a posterior estimation of both sparse coefficients and scaling variables are calculated efficiently by applying an alternating minimization method. Our experimental results prove that the proposed OCT super-resolution method based on the Laplacian+GEV model outperforms other competing methods in terms of both subjective and objective visual qualities.