Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984-2019)

(2020) Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984-2019). Phytochemistry Reviews. pp. 265-336. ISSN 1568-7767

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Abstract

Diterpene compounds specially macrocyclic ones comprising jatrophane, lathyrane, terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of the Euphorbiaceae family are of considerable interest in the context of natural product drug discovery programs. They possess diverse complex skeletons and a broad spectrum of therapeutically relevant biological activities including anti-inflammatory, anti-chikungunya virus, anti-HIV, cytotoxic, and multidrug resistance-reversing activities as well as curative effects on thrombotic diseases. Among macrocyclic diterpenes of Euphorbia, the discovery of jatrophane and modified jatrophane diterpenes with a wide range of structurally unique polyoxygenated polycyclic derivatives and as a new class of powerful inhibitors of P-glycoprotein has opened new frontiers for research studies on this genus. In this review, an attempt has been made to give in-depth coverage of the articles on the naturally occurring jatrophanes and rearranged jatrophane-type diterpenes isolated from species belonging to the Euphorbiaceae family published from 1984 to March 2019, with emphasis on the biogenesis, isolation methods, structure, biological activity, and structure-activity relationship.

Item Type: Article
Keywords: Natural products Euphorbia Jatrophane diterpenes Rearranged Jatrophanes Chromatography Multidrug resistance MULTIDRUG-RESISTANT CANCER P-GLYCOPROTEIN MODULATORS MDR-REVERSAL ACTIVITY MACROCYCLIC DITERPENES MOUSE LYMPHOMA IN-VITRO EUPHORBIA-DENDROIDES CHIKUNGUNYA VIRUS POTENT INHIBITORS BISHOMODITERPENE LACTONES
Subjects: QV Pharmacology
Divisions: Faculty of Pharmacy and Pharmaceutical Sciences
Page Range: pp. 265-336
Journal or Publication Title: Phytochemistry Reviews
Journal Index: ISI
Volume: 19
Number: 2
Identification Number: https://doi.org/10.1007/s11101-020-09667-8
ISSN: 1568-7767
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12530

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