Clinical display, diagnostics and genetic implication of Novel Coronavirus (COVID-19) epidemic

(2020) Clinical display, diagnostics and genetic implication of Novel Coronavirus (COVID-19) epidemic. European Review for Medical and Pharmacological Sciences. pp. 4607-4615. ISSN 1128-3602

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Abstract

COVID-19 pandemic can cause irreparable damage to the involved society. This study aimed to provide a summary of the up-to-dated clinical display, diagnostics, molecular and genetic implications for COVID-19 infected patients. In this review, 73 research articles published before 25 March 2020 were analyzed to better understand the clinical characteristics of patients and to introduce the available serological, hematology and molecular diagnostic methods. Apart from articles extracted from PubMed and Google Scholar, WHO (https://www.who.int/), NHC (National Health Commission of the People's Republic of China (http://www.nhc.gov.cn/), NICE (National Institute for Health and Clinical Excellence, https://www.nice.org.uk/), CDC (Centers for Disease Control and Prevention, https://www.cdc.gov/), and National Administration of Traditional Chinese Medicine (http://www. satcm.gov.cn/) were also accessed to search for eligible studies. Papers published between January 1, 2020, and 25 March 2020 were searched in English and the terms "2019-nCoV. Covid-19, Clinical Characteristics OR manifestation. method of detection, COVID-19 Genome and molecular test" were used. As the pandemic continues to evolve, there have been reports about the possibility of asymptomatic transmission of this newly emerged pneumonia virus. We highlighted the role of HLA haplotype in virus infection as HLA typing will provide susceptibility information for personalized prevention, diagnosis, and treatment in future studies. All the data in this article will assist researchers and clinicians to develop their clinical views regarding infected patients and to emphasize the origin of SARS-CoV-2 for diagnostics.

Item Type: Article
Keywords: Diagnosis Genetic Epidemiology Coronavirus SARS-CoV-2 COVID-19 Detection Clinical display Novel coronavirus ACUTE RESPIRATORY SYNDROME PNEUMONIA LESSONS WUHAN CHINA SARS
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
WC Communicable Diseases > WC 500-590 Virus Diseases
Divisions: Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Page Range: pp. 4607-4615
Journal or Publication Title: European Review for Medical and Pharmacological Sciences
Journal Index: ISI
Volume: 24
Number: 8
ISSN: 1128-3602
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/12555

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