Efficacy of fresh frozen plasma transfusion in comparison with conventional regimen in organophosphate poisoning treatment: a meta-analysis study

Abstract

Objective To evaluating the efficacy of fresh frozen plasma (FFP) in comparison with conventional regimen in the treatment of organophosphate (OP) poisoning. Methods PubMed, ScopeMed, Cochrane, Scopus, and Google Scholar databases were searched. The search strategy used the following key words "organophosphate" and "poisoning or toxicity", "(atropine and oxime)", "fresh frozen plasma", "clinical trial", "outcome". The treatment with atropine or/and oxime was considered conventional therapy. The length of hospitalization, the length of ICU admission, need for mechanical ventilation and its duration, clinical recovery point, choline esterase level, mortality rate, and intermediate syndrome (IMS) occurrence were the key outcomes of interest. Databases were searched during the period of 2003-2019. Five studies were included in the analysis. Results Pooling of data showed that the relative risk (RR) of mortality in OP poisoning for five included trials comparing FFP-treated group with conventional regimen therapy was 0.563 (95% CI (0.252, 1.255). The summary of RR for IMS in two studies was RR: 1.34, 95% CI (0.655, 2.742). In addition, there was a non-significant mean difference (MD) in hospital stay MD: -0.106, 95% CI (-0.434, 0.223) in three included trials. A significant MD was observed in the length of ICU admission in two trials between FFP-treated group compared to the conventional treatment group MD: -2.672, 95% CI (-4.189, -1.154), but after random effects meta-analysis, the changes were not significant MD: -2.015, 95% CI (-6.308, 2.277). The summary of fixed-effect meta-analysis for choline esterase level in three trails was MD: -0.117, 95% CI (-0.468, 0.234). The RR of ventilation requirement for two included trials in the FFP-treated group comparing to the conventional regimen therapy was 0.84, 95% CI (0.691, 1.022) while for ventilation duration in two studies was MD: -0.183, 95% CI (-0.567, 0.201). Conclusion The addition of FFP to conventional therapy did not improve the outcomes of mortality, IMS, hospital length of stay, cholinesterase levels, need or duration of mechanical ventilation, and only the length of ICU stay could affect in the treated group.