Organ Doses, Effective Dose, and Cancer Risk From Coronary CT Angiography Examinations

Abstract

OBJECTIVE. The purposes of this study were to determine organ and effective doses and to estimate the risk of exposure-induced cancer death (REID) associated with coronary CT angiography (CCTA) examinations. SUBJECTS AND METHODS. CCTA examinations were performed in three stages: calcium score, monitoring, and cardiac phases for all patients. Effective dose was calculated using two methods. The first was based on the scanner- derived dose-length product, and the second entailed use of an organ and effective dose calculator software application. Organ doses were calculated on the basis of the tissue weighting factors of International Commission on Radiation Protection report 103. REID values were assessed with a cancer risk estimator software application. RESULTS. The study included 185 patients (95 men, 90 women). For women, breast doses were high at 52.04 +/- 14.08 mGy. The mean effective dose in the women was greater than that in the men (24.05 vs 16.30 mSv, p < 0.05). The mean REID values in patients undergoing CCTA with a 64-MDCT scanner were 13.4 per 10,000 men (1 in 746) and 19.6 per 10,000 women (1 in 508). The REID values were considerably higher for the younger women. CONCLUSION. The results of this study will help referring physicians justify requesting CCTA examinations by considering their benefits for diagnosis on the one hand and awareness of the risk of radiation-induced cancer on the other. In the case of CCTA scans that are properly justified by clinical indication, patients and physicians should not be concerned about the radiation risks.