(2020) Covalent triazine-based polyimine framework as a biocompatible pH-dependent sustained-release nanocarrier for sorafenib: An in vitro approach. Journal of Molecular Liquids. ISSN 0167-7322
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Abstract
In the present study, a novel polyimine-based covalent triazine framework (PI-CTF) was introduced as a promising biocompatible carrier for sorafenib (SFN) delivery. High specific surface area and porosity allowed us to achieve drug loading and encapsulation efficiency as high as 83 and 98, respectively. The in vitro drug release study of SFN-loaded PI-CTF showed a sustained and pH-dependent release behavior in which acidic pH accelerated drug release compared with the neutral pH. Notably, cytotoxicity assay against L929 cells revealed the safety and biocompatibility of PI-CTF. Moreover, MTT assay against LNCaP prostate cancer cells expressed that the anticancer activity of SFN had no diminution after incorporating into PI-CTF. Thus, PI-CTF has envisaged as a great promise toward anti-cancer drug carrier. (C) 2019 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Covalent triazine-based framework CTF Sorafenib Drug delivery Drug controlled release ORGANIC FRAMEWORK ANTITUMOR EFFICACY DRUG-DELIVERY POLYMERIC NANOPARTICLES COPOLYMERIC MICELLES EFFICIENT REMOVAL BREAST-CANCER ENCAPSULATION CYTOTOXICITY DOCETAXEL |
| Subjects: | QV Pharmacology QZ Pathology > QZ 200-380 Neoplasms |
| Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmaceutical Biotechnology Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacotherapy |
| Journal or Publication Title: | Journal of Molecular Liquids |
| Journal Index: | ISI |
| Volume: | 297 |
| Identification Number: | https://doi.org/10.1016/j.molliq.2019.111898 |
| ISSN: | 0167-7322 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/13212 |
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