Evaluation of magnesium level and associated factors in patients under peritoneal dialysis

Abstract

Background: Given the high prevalence of chronic renal failure worldwide, and the fact that kidneys are the major means of magnesium excretion from the body, it is speculated that the incidence risk of magnesium balance disorder would be high in patients under peritoneal dialysis. The aim of the present study was to evaluate the mentioned patients' magnesium level and specify the effective factors in this regard. Methods: The present cross-sectional study was performed on 210 patients undergoing peritoneal dialysis that referred to Alzahra and Khorshid hospitals in Isfahan City, Iran. Patients' demographic data such as age, sex, education status, cause of failure, type of comorbidity, duration of dialysis, and type of dialysis solution were recorded. In addition, the patients' serum levels of magnesium, calcium, parathyroid hormone, and KT/V renal levels (in which K was dialyzer clearance of urea, T was dialysis time, and V was the volume of distribution of urea in patient's total body) were also assessed. Findings: The patients' mean magnesium level was 2.39 ± 0.39 mg/dl. There was no significant difference in the magnesium level between the men and women. Moreover, no significant difference was observed among the administrations of various dialysis solutions including dextrose 1.5, 2.5, and 4.25 as well as icodextrin 7.5 (P > 0.05). However, hypertension had a significant inverse effect with magnesium level (coefficient effect : -0.100; P < 0.05). Conclusion: According to the results of the present study, the magnesium level was normal in patients under peritoneal dialysis. However, hypertension had a significant reverse effect on magnesium level, which was lower in patients with hypertension. © 2020 Isfahan University of Medical Sciences(IUMS). All rights reserved.