(2020) Sorafenib loaded pluronic F127-lithocholic acid micelles for prostate cancer therapy: Formulation, optimization, and in vitro evaluation against LNCaP cells. International Journal of Polymeric Materials and Polymeric Biomaterials. pp. 158-172. ISSN 0091-4037
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Abstract
In present study, sorafenib loaded nanomicelles were prepared with synthesized pluronic F127 - lithocholic acid by film hydration method. The optimized micelles were spherical showing particle size of 319.36 nm, zeta potential of -11.96 mV, encapsulation efficiency of 87.31, loading efficiency of 14.87 and release efficiency of 30.1. Sorafenib loaded nanomicelles showed negligible hemolysis activity on RBC, indicating excellent hemocompatibility of pluronic F127 - lithocholic acid. The drug free nanomicelles showed no cytotoxicity against L929 cells by using MTT assay. However, micellar sorafenib showed more anti-proliferation effect on LNCaP and DU145 cells as compared with free sorafenib.
| Item Type: | Article |
|---|---|
| Keywords: | Prostate cancer polymeric micelles sorafenib pluronic F127-lithocholic acid conjugate LNCaP cells TARGETED DRUG-DELIVERY POLYMERIC MICELLES AMPHIPHILIC COPOLYMER MIXED MICELLES NANOPARTICLES BIOAVAILABILITY DOCETAXEL PHARMACOKINETICS BIODISTRIBUTION SOLUBILIZATION |
| Subjects: | QV Pharmacology QZ Pathology > QZ 200-380 Neoplasms WJ Urogenital System > WJ 700-875 Male Genitalia |
| Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > گروه شیمی دارویی Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacotherapy Novel Drug Delivery Systems Research Center |
| Page Range: | pp. 158-172 |
| Journal or Publication Title: | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Journal Index: | ISI |
| Volume: | 69 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.1080/00914037.2018.1552860 |
| ISSN: | 0091-4037 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/13327 |
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