(2020) Fatal Invasive Pulmonary Aspergillosis in COVID-19 Patient with Acute Myeloid Leukemia in Iran. Mycopathologia. pp. 1077-1084. ISSN 0301-486X
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Abstract
Although patients with severe immunodeficiency and hematological malignancies has been considered at highest risk for invasive fungal infection, patients with severe pneumonia due to influenza, and severe acute respiratory syndrome coronavirus (SARS-CoV) are also at a higher risk of developing invasive pulmonary aspergillosis (IPA). Recently, reports of IPA have also emerged among SARS-CoV-2 infected patients admitted to intensive care units (ICUs). Here, we report a fatal case of probable IPA in an acute myeloid leukemia patient co-infected with SARS-CoV-2 and complicated by acute respiratory distress syndrome (ARDS). Probable IPA is supported by multiple pulmonary nodules with ground glass opacities which indicate halo sign and positive serum galactomannan results. Screening studies are needed to evaluate the prevalence of IPA in immunocompromised patients infected with SARS-CoV-2. Consequently, testing for the presence ofAspergillusin lower respiratory secretions and galactomannan in consecutive serum samples of COVID-19 patients with timely and targeted antifungal therapy based on early clinical suspicion of IPA are highly recommended.
Item Type: | Article |
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Keywords: | COVID-19 SARS-CoV-2 Aspergillosis Acute myeloid leukemia |
Subjects: | WC Communicable Diseases > WC 500-590 Virus Diseases WF Respiratory System |
Divisions: | Faculty of Medicine > Departments of Clinical Sciences > Department of Internal Faculty of Paramedical > Department of Radiology Infectious Diseases and Tropical Medicine Research Center Psychosomatic Research Center Other |
Page Range: | pp. 1077-1084 |
Journal or Publication Title: | Mycopathologia |
Journal Index: | ISI |
Volume: | 185 |
Number: | 6 |
Identification Number: | https://doi.org/10.1007/s11046-020-00493-2 |
ISSN: | 0301-486X |
Depositing User: | Zahra Otroj |
URI: | http://eprints.mui.ac.ir/id/eprint/13338 |
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