Fatal Invasive Pulmonary Aspergillosis in COVID-19 Patient with Acute Myeloid Leukemia in Iran

(2020) Fatal Invasive Pulmonary Aspergillosis in COVID-19 Patient with Acute Myeloid Leukemia in Iran. Mycopathologia. pp. 1077-1084. ISSN 0301-486X

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Abstract

Although patients with severe immunodeficiency and hematological malignancies has been considered at highest risk for invasive fungal infection, patients with severe pneumonia due to influenza, and severe acute respiratory syndrome coronavirus (SARS-CoV) are also at a higher risk of developing invasive pulmonary aspergillosis (IPA). Recently, reports of IPA have also emerged among SARS-CoV-2 infected patients admitted to intensive care units (ICUs). Here, we report a fatal case of probable IPA in an acute myeloid leukemia patient co-infected with SARS-CoV-2 and complicated by acute respiratory distress syndrome (ARDS). Probable IPA is supported by multiple pulmonary nodules with ground glass opacities which indicate halo sign and positive serum galactomannan results. Screening studies are needed to evaluate the prevalence of IPA in immunocompromised patients infected with SARS-CoV-2. Consequently, testing for the presence ofAspergillusin lower respiratory secretions and galactomannan in consecutive serum samples of COVID-19 patients with timely and targeted antifungal therapy based on early clinical suspicion of IPA are highly recommended.

Item Type: Article
Keywords: COVID-19 SARS-CoV-2 Aspergillosis Acute myeloid leukemia
Subjects: WC Communicable Diseases > WC 500-590 Virus Diseases
WF Respiratory System
Divisions: Faculty of Medicine > Departments of Clinical Sciences > Department of Internal
Faculty of Paramedical > Department of Radiology
Infectious Diseases and Tropical Medicine Research Center
Psychosomatic Research Center
Other
Page Range: pp. 1077-1084
Journal or Publication Title: Mycopathologia
Journal Index: ISI
Volume: 185
Number: 6
Identification Number: https://doi.org/10.1007/s11046-020-00493-2
ISSN: 0301-486X
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/13338

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