Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

(2020) Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends. Materials.

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Abstract

Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

Item Type: Article
Keywords: 3D printing chitosan bio-inks scaffolds fabrication process drug delivery tissue engineering biomedical applications MECHANICAL-PROPERTIES IN-VITRO HYDROXYAPATITE SCAFFOLDS BIOMEDICAL APPLICATIONS NANOCOMPOSITE COATINGS COMPOSITE SCAFFOLDS DRUG-DELIVERY CELL-GROWTH HYDROGEL CHITIN
Subjects: QS Human Anatomy > QS504-532 Histology
W General Medicine. Health Professions > W 82-83.1 Biomedical Technology
Divisions: Faculty of Medicine > Department of Basic Science > Department of Anatomical Sciences
School of Advanced Technologies in Medicine > Department of Biomaterials, Nanotechnology and Tissue Engineering
Journal or Publication Title: Materials
Journal Index: ISI
Volume: 13
Number: 11
Identification Number: https://doi.org/10.3390/ma13112663
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/13390

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