Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review

(2020) Electrospun Nano-Fibers for Biomedical and Tissue Engineering Applications: A Comprehensive Review. Materials.

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Abstract

Pharmaceutical nano-fibers have attracted widespread attention from researchers for reasons such as adaptability of the electro-spinning process and ease of production. As a flexible method for fabricating nano-fibers, electro-spinning is extensively used. An electro-spinning unit is composed of a pump or syringe, a high voltage current supplier, a metal plate collector and a spinneret. Optimization of the attained nano-fibers is undertaken through manipulation of the variables of the process and formulation, including concentration, viscosity, molecular mass, and physical phenomenon, as well as the environmental parameters including temperature and humidity. The nano-fibers achieved by electro-spinning can be utilized for drug loading. The mixing of two or more medicines can be performed via electro-spinning. Facilitation or inhibition of the burst release of a drug can be achieved by the use of the electro-spinning approach. This potential is anticipated to facilitate progression in applications of drug release modification and tissue engineering (TE). The present review aims to focus on electro-spinning, optimization parameters, pharmacological applications, biological characteristics, and in vivo analyses of the electro-spun nano-fibers. Furthermore, current developments and upcoming investigation directions are outlined for the advancement of electro-spun nano-fibers for TE. Moreover, the possible applications, complications and future developments of these nano-fibers are summarized in detail.

Item Type: Article
Keywords: electrospinning fabrication parameters effect nano-fibers drug delivery wound dressing POLY LACTIC-ACID DRUG-DELIVERY IN-VITRO CONTROLLED-RELEASE ANTIBACTERIAL ACTIVITY NANOFIBROUS SCAFFOLDS CHITOSAN NANOFIBERS ULTRAFINE FIBERS POTENTIAL APPLICATION OXIDE NANOPARTICLES
Subjects: W General Medicine. Health Professions > W 82-83.1 Biomedical Technology
Divisions: School of Advanced Technologies in Medicine > Department of Biomaterials, Nanotechnology and Tissue Engineering
Journal or Publication Title: Materials
Journal Index: ISI
Volume: 13
Number: 9
Identification Number: https://doi.org/10.3390/ma13092153
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/13404

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