(2020) Two new dammarane triterpenes isolated from Cleome khorassanica Bunge & Bien with cytotoxicity against DU-145 and LNCaP prostate cancer cell lines. Journal of Asian Natural Products Research. pp. 38-46. ISSN 1028-6020
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Abstract
From the aerial parts of Cleome khorassanica Bunge & Bien, a new 3-oxo-4-oxa-A-homo-25,26,27-trinordammarano-24,20-lactone triterpene (1), a new natural product 20,25-dihydroxy-3-oxodammarane triterpene (2), together with known 5-hydroxy-3,6,7,8,3 ',4 ',5 '-heptamethoxyflavone (3), have been isolated and characterized. The chemical structure of the new compounds was determined by 1D and 2D NMR and HR tandem MS measurements. All three compounds were subjected to biological tests for evaluation of their cytotoxicity against prostate (DU-145 and LNCaP) cancer cells. Compounds 1, 2, and 3 showed cell growth inhibition in a dose dependent manner against DU-145 and LNCaP cells.
| Item Type: | Article |
|---|---|
| Keywords: | Cleome khorassanica dammarane triterpene prostate cancer cells Iran flora SAPONINS |
| Subjects: | QV Pharmacology QV Pharmacology > QV 600-666 Toxicology QZ Pathology > QZ 200-380 Neoplasms |
| Divisions: | Faculty of Pharmacy and Pharmaceutical Sciences > Department of Clinical Biochemistry Faculty of Pharmacy and Pharmaceutical Sciences > Department of Pharmacognosy Isfahan Pharmaceutical Sciences Research center |
| Page Range: | pp. 38-46 |
| Journal or Publication Title: | Journal of Asian Natural Products Research |
| Journal Index: | ISI |
| Volume: | 22 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1080/10286020.2018.1538211 |
| ISSN: | 1028-6020 |
| Depositing User: | Zahra Otroj |
| URI: | http://eprints.mui.ac.ir/id/eprint/13583 |
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