Gastric Cancer Diagnosis: From Imaging techniques to Biochemical Biomarkers

Abstract

Gastric cancer (GC) is found as the second leading cause of cancer associated deaths in the world which is usually detected in the advanced stages. It has been showed that surgery is major therapeutic approach in the treatment subjects with GC. Hence, early and fast diagnosis of this malignancy is very important issue for good subject outcomes. Noninvasive diagnostic platforms including evolutionary endoscopy and positron emission tomography (PET) are employed as diagnosis for subjects with GC. Along to imaging techniques, utilization of biomarkers has been emerged as new diagnosis options in early and fast detection of GC. Multiple lines evidence revealed, a variety of biomarkers including microRNAs, exosomes, circulating tumor cells, circular RNAs, cell free DNAs, and various proteins could be used as diagnostic biomarkers in patients with GC. Taken together, these findings suggested that joint application of imaging techniques and different biomarkers, could be introduced as new detection approaches in the treatment and screening response to therapy in the subjects with GC. Herein, we summarized various imaging techniques and biomarkers as powerful tools in the detection of GC.