Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review

(2020) Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review. Molecular and Cellular Probes. ISSN 0890-8508

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Abstract

The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.

Item Type: Article
Keywords: Aptamer Probe Therapy Coronavirus COVID-19 SARS MFRS SARS-CoV-2 SARS CORONAVIRUS NUCLEOCAPSID PROTEIN DNA APTAMERS RNA HELICASES
Subjects: QW Microbiology and Immunology > QW 1-300 Microbiology
Divisions: Faculty of Medicine > Department of Basic Science > Department of Microbiology
Journal or Publication Title: Molecular and Cellular Probes
Journal Index: ISI
Volume: 53
Identification Number: https://doi.org/10.1016/j.mcp.2020.101636
ISSN: 0890-8508
Depositing User: Zahra Otroj
URI: http://eprints.mui.ac.ir/id/eprint/13815

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